Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.60 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.60 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.60 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.60 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL437167 | 0.88 | PDCD1 (0.49) | CHRNB2CHRNA4CHRNB4CHRNA3TAS1R3 | |
| SCHEMBL7697059 | 0.87 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3TAS1R3 | |
| SCHEMBL1649572 | 0.83 | CHRNB2 (0.68) | CHRNB2CHRNA4CHRNB4CHRNA3GAA | |
| SCHEMBL11007801 | 0.83 | CHRNB2 (0.72) | CHRNB2CHRNA4CHRNB4CHRNA3GAA | |
| SCHEMBL7217604 | 0.80 | CHRNB2 (0.68) | CHRNB2CHRNA4CHRNB4CHRNA3TAS1R3 | |
| SCHEMBL13163159 | 0.79 | HPGD (0.58) | MAPK1LMNAKMT2AMEN1 | |
| SCHEMBL15297335 | 0.78 | HPGD (0.56) | GAALMNAKMT2AMEN1 | |
| SCHEMBL17450379 | 0.78 | HPGD (0.49) | GAAHTTLMNAKMT2AMEN1 | |
| SCHEMBL14067301 | 0.78 | MEN1 (0.45) | GAAMAPK1KMT2AMEN1KDM4E | |
| SCHEMBL2491198 | 0.78 | HPGD (0.58) | POLBLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |