Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947145 | 0.92 | HSD11B1 (0.59) | HSD11B1ALDH1A1HTTPOLBHDAC6 | |
| SCHEMBL8947132 | 0.91 | HSD11B1 (0.57) | HSD11B1ALDH1A1HTTPOLBHDAC6 | |
| SCHEMBL8947294 | 0.86 | MAPK1 (0.61) | HSD11B1ALDH1A1HTTPOLBHDAC6 | |
| SCHEMBL408080 | 0.83 | HSD11B1 (0.72) | HSD11B1ALDH1A1HTTPOLBHDAC6 | |
| SCHEMBL8947202 | 0.83 | HSD11B1 (0.76) | HSD11B1ALDH1A1HTTPOLBHDAC6 | |
| SCHEMBL10972067 | 0.80 | HSD11B1 (0.60) | HSD11B1ALDH1A1HTTPOLBHDAC6 | |
| SCHEMBL5593165 | 0.79 | HSD11B1 (1.00) | HSD11B1ALDH1A1HTTPOLBHDAC6 | |
| SCHEMBL10969221 | 0.78 | HSD11B1 (0.57) | HSD11B1ALDH1A1HTTPOLBHDAC6 | |
| SCHEMBL4408289 | 0.78 | ALDH1A1 (0.71) | HSD11B1ALDH1A1HTTPOLBHDAC6 | |
| SCHEMBL8921457 | 0.77 | MAPK1 (0.53) | HSD11B1ALDH1A1POLBTSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |