Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26579684 | 0.84 | MAPK1 (0.76) | MAPK1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL30739865 | 0.84 | GPR139 (0.59) | GPR139NPC1RAB9AHDAC1HDAC6 | |
| SCHEMBL13144463 | 0.83 | MAPK1 (0.62) | MAPK1GPR139NPC1RAB9AHDAC6 | |
| SCHEMBL2204173 | 0.83 | NPC1 (0.57) | GPR139NPC1RAB9AHDAC1HDAC6 | |
| SCHEMBL31148337 | 0.82 | HDAC1 (0.61) | GPR139NPC1RAB9AHDAC1HDAC6 | |
| SCHEMBL8947129 | 0.82 | POLB (0.68) | MAPK1GPR139HDAC1ALDH1A1LMNA | |
| SCHEMBL6160025 | 0.81 | MAPK1 (0.60) | MAPK1KDM4EALDH1A1GAAMEN1 | |
| SCHEMBL8947214 | 0.81 | MAPK1 (0.72) | MAPK1GPR139NPC1RAB9AKDM4E | |
| SCHEMBL31178805 | 0.81 | MAPK1 (0.72) | MAPK1GPR139NPC1RAB9AKDM4E | |
| SCHEMBL10064202 | 0.81 | MEN1 (0.65) | MAPK1GPR139NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |