Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790731 | 0.85 | ALDH1A1 (0.49) | MAPK1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL8947195 | 0.78 | TRPV1 (0.44) | MAPK1TRPV1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL8947317 | 0.76 | ALDH1A1 (0.57) | MAPK1TRPV1HDAC6ALDH1A1HPGD | |
| SCHEMBL8791353 | 0.75 | TRPV1 (0.41) | MAPK1TRPV1HDAC3HDAC1HDAC2 | |
| SCHEMBL8947240 | 0.75 | ALDH1A1 (0.54) | MAPK1TRPV1HDAC6ALDH1A1HPGD | |
| SCHEMBL8947277 | 0.75 | TRPV1 (0.50) | MAPK1TRPV1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL5966689 | 0.72 | TRPV1 (0.59) | TRPV1HDAC6ALDH1A1HPGDCYP1A2 | |
| SCHEMBL8947122 | 0.72 | ALDH1A1 (0.47) | MAPK1TRPV1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL13631407 | 0.72 | MAPK1 (0.72) | MAPK1TRPV1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL9730904 | 0.72 | TRPV1 (0.43) | MAPK1TRPV1ALDH1A1HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |