Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947242 | 0.88 | KMT2A (0.67) | KMT2AMEN1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL19859082 | 0.86 | RAB9A (0.63) | KMT2AMEN1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8947346 | 0.85 | ALDH1A1 (0.58) | KMT2AMEN1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL19948182 | 0.84 | PRSS1 (0.51) | KMT2AMEN1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL19859085 | 0.81 | RAB9A (0.58) | KMT2AMEN1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24224262 | 0.81 | KMT2A (0.59) | KMT2AMEN1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL13330080 | 0.81 | KDM4E (0.62) | KMT2AMEN1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL834861 | 0.81 | KMT2A (0.59) | KMT2AMEN1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL8283407 | 0.81 | TDP1 (0.71) | KMT2AMEN1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL30838576 | 0.81 | KDM4E (0.62) | KMT2AMEN1SMN1; SMN2KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |