Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 9/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947163 | 0.89 | TRPV1 (0.39) | PTGS1TRPV1VCAM1PTGS2MAPK1 | |
| SCHEMBL8947341 | 0.86 | ALDH1A1 (0.53) | PTGS1PTGS2CA1CA2ALDH1A1 | |
| SCHEMBL8947195 | 0.81 | TRPV1 (0.44) | TRPV1MAPK1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL8947317 | 0.80 | ALDH1A1 (0.57) | TRPV1MAPK1ALDH1A1HPGDPOLB | |
| SCHEMBL8947143 | 0.80 | TRPV1 (0.49) | TRPV1MAPK1ALDH1A1HPGDPOLB | |
| SCHEMBL8947174 | 0.78 | ALDH1A1 (0.50) | PTGS1PTGS2ALDH1A1HPGDCYP1A2 | |
| SCHEMBL8947118 | 0.77 | KDM4E (0.42) | TRPV1PTGS2MAPK1ALDH1A1HPGD | |
| SCHEMBL8947240 | 0.76 | ALDH1A1 (0.54) | TRPV1MAPK1ALDH1A1HPGDPOLB | |
| SCHEMBL5966689 | 0.76 | TRPV1 (0.59) | TRPV1ALDH1A1HPGDPOLBCYP1A2 | |
| SCHEMBL8947122 | 0.75 | ALDH1A1 (0.47) | TRPV1MAPK1ALDH1A1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |