Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.37 |
| ▸ | GLRB | P48167 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947282 | 0.86 | PTGS1 (0.46) | ALDH1A1HPGDCA2CA1CYP1A2 | |
| SCHEMBL8947174 | 0.86 | ALDH1A1 (0.50) | ALDH1A1HPGDCYP1A2PTGS1PTGS2 | |
| SCHEMBL8947259 | 0.80 | ALDH1A1 (0.61) | ALDH1A1HPGDCYP1A2LMNAPOLB | |
| SCHEMBL8947265 | 0.78 | ALDH1A1 (0.68) | ALDH1A1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL8947331 | 0.76 | ALDH1A1 (0.84) | ALDH1A1HPGDLMNAPOLB | |
| SCHEMBL8947163 | 0.74 | TRPV1 (0.39) | ALDH1A1HPGDCYP1A2PTGS1PTGS2 | |
| SCHEMBL8947281 | 0.74 | ALDH1A1 (0.75) | ALDH1A1HPGDPOLB | |
| SCHEMBL5966727 | 0.74 | ALDH1A1 (0.75) | ALDH1A1HPGDPTGS2POLB | |
| SCHEMBL8947275 | 0.73 | ALDH1A1 (0.61) | ALDH1A1HPGDCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8947333 | 0.73 | ALDH1A1 (0.65) | ALDH1A1HPGDCYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |