Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | STAT5B | P51692 | 1/20 | 0.39 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947331 | 0.88 | ALDH1A1 (0.84) | ALDH1A1HPGDHSD11B1KDM4CHDAC6 | |
| SCHEMBL5966727 | 0.85 | ALDH1A1 (0.75) | ALDH1A1HPGDMAPTHSD11B1KDM4C | |
| SCHEMBL8947218 | 0.85 | MAPT (0.49) | ALDH1A1HPGDMAPTMAPK1HSD11B1 | |
| SCHEMBL8947281 | 0.82 | ALDH1A1 (0.75) | ALDH1A1HPGDHSD11B1KDM4CHDAC6 | |
| SCHEMBL8947261 | 0.82 | ALDH1A1 (0.75) | ALDH1A1HPGDHSD11B1KDM4CHDAC6 | |
| SCHEMBL5966693 | 0.82 | ALDH1A1 (0.74) | ALDH1A1HPGDHSD11B1KDM4CHDAC6 | |
| SCHEMBL8947199 | 0.81 | ALDH1A1 (0.73) | ALDH1A1HPGDHSD11B1KDM4CHDAC6 | |
| SCHEMBL8947183 | 0.81 | ALDH1A1 (0.73) | ALDH1A1HPGDHSD11B1KDM4CHDAC6 | |
| SCHEMBL8947260 | 0.81 | ALDH1A1 (0.73) | ALDH1A1HPGDHSD11B1KDM4CHDAC6 | |
| SCHEMBL8947164 | 0.81 | ALDH1A1 (1.00) | ALDH1A1HPGDHSD11B1KDM4CHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |