Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.58 |
| ▸ | PPARG | P37231 | 2/20 | 0.56 |
| ▸ | PPARA | Q07869 | 1/20 | 0.56 |
| ▸ | RARB | P10826 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947350 | 0.96 | MMP1 (0.72) | MMP1POLB | |
| SCHEMBL19781425 | 0.87 | MMP1 (0.68) | MMP1POLBTP53TSHRPLA2G4B | |
| SCHEMBL1000025 | 0.87 | MMP1 (0.68) | MMP1POLBTP53TSHRPLA2G4B | |
| SCHEMBL28570651 | 0.85 | NPC1 (0.68) | MMP1TP53TSHRPLA2G4B | |
| SCHEMBL12638372 | 0.85 | MMP1 (0.65) | MMP1POLBTP53TSHRPLA2G4B | |
| SCHEMBL12243300 | 0.84 | MMP1 (0.64) | MMP1POLBTP53TSHRPLA2G4B | |
| SCHEMBL11758823 | 0.84 | NPC1 (0.72) | MMP1TP53TSHRPLA2G4B | |
| SCHEMBL9490019 | 0.84 | NPC1 (0.72) | MMP1TP53TSHRPLA2G4B | |
| SCHEMBL12672309 | 0.84 | SPHK1 (0.65) | MMP1POLBTP53TSHRPLA2G4B | |
| SCHEMBL13569633 | 0.84 | SPHK1 (0.65) | MMP1POLBTP53TSHRPLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |