Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.53 |
| ▸ | PTGIR | P43119 | 4/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | GABRP | O00591 | 3/20 | 0.47 |
| ▸ | GABRD | O14764 | 3/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947319 | 0.95 | HSD11B1 (0.68) | HSD11B1ALDH1A1POLBHTTP2RX7 | |
| SCHEMBL8947202 | 0.89 | HSD11B1 (0.76) | HSD11B1ALDH1A1POLBHTTP2RX7 | |
| SCHEMBL8947132 | 0.84 | HSD11B1 (0.57) | HSD11B1ALDH1A1POLBHTTP2RX7 | |
| SCHEMBL10635294 | 0.83 | ALDH1A1 (0.62) | HSD11B1ALDH1A1POLBHTTP2RX7 | |
| SCHEMBL10628893 | 0.82 | ALDH1A1 (0.60) | HSD11B1ALDH1A1POLBHTTP2RX7 | |
| SCHEMBL10635559 | 0.82 | ALDH1A1 (0.60) | HSD11B1ALDH1A1POLBHTTP2RX7 | |
| SCHEMBL10972067 | 0.81 | HSD11B1 (0.60) | HSD11B1ALDH1A1POLBHTTP2RX7 | |
| SCHEMBL408080 | 0.81 | HSD11B1 (0.72) | HSD11B1ALDH1A1POLBHTTP2RX7 | |
| SCHEMBL8653064 | 0.80 | ALDH1A1 (0.62) | HSD11B1ALDH1A1POLBHTTP2RX7 | |
| SCHEMBL4407364 | 0.80 | ALDH1A1 (0.62) | HSD11B1ALDH1A1POLBHTTP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |