Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 9/20 | 0.51 |
| ▸ | DPP4 | P27487 | 5/20 | 0.50 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8784775 | 0.86 | TACR1 (0.55) | TACR1DPP4KCNA5KCNH2 | |
| SCHEMBL8785047 | 0.86 | DPP4 (0.72) | TACR1DPP4KCNA5KCNH2 | |
| SCHEMBL2902940 | 0.84 | KCNA5 (0.71) | TACR1DPP4KCNA5KCNH2SMN1; SMN2 | |
| SCHEMBL5235622 | 0.80 | DPP4 (0.72) | TACR1DPP4KCNA5KCNH2 | |
| SCHEMBL8785517 | 0.80 | TACR1 (0.54) | TACR1DPP4KCNA5KCNH2LMNA | |
| SCHEMBL12499137 | 0.78 | TACR1 (0.42) | TACR1DPP4POLBTDP1LMNA | |
| SCHEMBL8947966 | 0.78 | TACR1 (0.56) | TACR1DPP4KCNA5KCNH2LMNA | |
| SCHEMBL8947816 | 0.78 | DPP4 (0.74) | TACR1DPP4KCNA5KCNH2TDP1 | |
| SCHEMBL4686848 | 0.74 | TACR1 (0.49) | TACR1DPP4KCNA5KCNH2LMNA | |
| SCHEMBL1376897 | 0.74 | KMT2A (0.51) | TACR1DPP4KCNA5KCNH2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527811-A | CALCIUM- AND SUBSTANCE P RECEPTOR-ANTAGONIST ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0634402-A1 | Isochinolinone derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1995-01-18 | — | — | EP | disclosed |