Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 12/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947966 | 0.90 | TACR1 (0.56) | TACR1DPP4LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL8948131 | 0.80 | TACR1 (0.55) | TACR1MAPK14LMNAKDM4EKMT2A | |
| SCHEMBL8784483 | 0.77 | TACR1 (0.56) | TACR1DPP4 | |
| SCHEMBL8784994 | 0.77 | DPP4 (0.73) | TACR1DPP4KDM4E | |
| SCHEMBL8785517 | 0.76 | TACR1 (0.54) | TACR1DPP4LMNAKDM4EKMT2A | |
| SCHEMBL14810050 | 0.74 | HMGCR (0.49) | MAPK14LMNAKDM4EKMT2A | |
| SCHEMBL9764062 | 0.74 | CDC25A (0.44) | TACR1MAPK14DPP4LMNAKDM4E | |
| SCHEMBL12498561 | 0.73 | MEN1 (0.45) | TACR1DPP4LMNAKDM4EKMT2A | |
| SCHEMBL18779955 | 0.73 | MAPT (0.42) | KDM4EKMT2A | |
| SCHEMBL8947989 | 0.73 | THRB (0.51) | TACR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527811-A | CALCIUM- AND SUBSTANCE P RECEPTOR-ANTAGONIST ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0634402-A1 | Isochinolinone derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1995-01-18 | — | — | EP | disclosed |