Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | DPP4 | P27487 | 6/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CASR | P41180 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8948020 | 0.92 | MAPT (0.51) | NAMPTMAPTDPP4TRPV1TACR1 | |
| SCHEMBL8947848 | 0.89 | DPP4 (0.57) | MAPTDPP4MAPK8TACR1 | |
| SCHEMBL8947988 | 0.89 | DPP4 (0.56) | MAPTDPP4MAPK8TACR1 | |
| SCHEMBL8947983 | 0.89 | DPP4 (0.56) | MAPTDPP4MAPK8TACR1 | |
| SCHEMBL8947987 | 0.87 | DPP4 (0.54) | MAPTDPP4MAPK8TACR1 | |
| SCHEMBL8947904 | 0.86 | DPP4 (0.52) | MAPTDPP4MAPK8TACR1ALDH1A1 | |
| SCHEMBL8947995 | 0.83 | TACR1 (0.56) | MAPTDPP4MAPK8KMT2AMEN1 | |
| SCHEMBL8948142 | 0.83 | LSS (0.53) | DPP4MAPK8TACR1 | |
| SCHEMBL8948077 | 0.82 | DPP4 (0.55) | MAPTDPP4MAPK8KMT2AMEN1 | |
| SCHEMBL8947979 | 0.82 | DPP4 (0.54) | MAPTDPP4MAPK8KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527811-A | CALCIUM- AND SUBSTANCE P RECEPTOR-ANTAGONIST ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0634402-A1 | Isochinolinone derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1995-01-18 | — | — | EP | disclosed |