SCHEMBL8949095

SCHEMBL8949095

COC(=O)C1CCC(NCCc2ccccc2)CC1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.61
GRIN2B Q13224 5/20 0.54
MAPT P10636 3/20 0.52
ALDH1A1 P00352 2/20 0.52
KDM4E B2RXH2 1/20 0.52
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
OPRM1 P35372 1/20 0.51
OPRL1 P41146 1/20 0.51
HPGD P15428 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
HSD17B10 Q99714 1/20 0.50
DRD4 P21917 1/20 0.47
TSHR P16473 2/20 0.45
NPC1 O15118 1/20 0.45
TP53 P04637 1/20 0.45
EPHX1 P07099 1/20 0.45
EPHX2 P34913 1/20 0.45
RAB9A P51151 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9175964 0.91 OPRM1 (0.55) TAAR1GRIN2BMAPTALDH1A1OPRM1
SCHEMBL2405273 0.85 ALDH1A1 (0.52) GRIN2BMAPTALDH1A1MEN1KMT2A
SCHEMBL2405274 0.85 ALDH1A1 (0.52) GRIN2BMAPTALDH1A1MEN1KMT2A
Ammonia Solution, Strong SCHEMBL3644104 0.84 ALDH1A1 (0.51) GRIN2BMAPTALDH1A1MEN1KMT2A
SCHEMBL10436171 0.83 CYP2C19 (0.61) TAAR1MAPTALDH1A1KDM4EMEN1
SCHEMBL7274110 0.83 CYP2C19 (0.61) TAAR1MAPTALDH1A1KDM4EMEN1
SCHEMBL662411 0.81 GRIN2B (0.76) TAAR1GRIN2BMAPTMEN1KMT2A
SCHEMBL22299601 0.80 TAAR1 (0.51) TAAR1MAPTALDH1A1KDM4EMEN1
SCHEMBL16499644 0.79 ALDH1A1 (0.52) MAPTALDH1A1MEN1KMT2AOPRM1
SCHEMBL16499642 0.79 ALDH1A1 (0.52) MAPTALDH1A1MEN1KMT2AOPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5563268-A FOR PREVENTING CELL AGGLOMERATION, TREATING THROMBOSIS, ARTERIOSCLEROSIS, BRAIN, LUNG OR CARDIOVASCULAR DISORDERS DR. KARL THOMAE GMBH (DE) 1996-10-08 US disclosed
US-5418233-A FOR INHIBITING CELL AGGREGATION KARL THOMAE GMBH (DE) 1995-05-23 US disclosed