Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 8/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MELK | Q14680 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8407957 | 0.89 | POLB (0.43) | HRH3ITGB3ITGA2BHTR2BPOLB | |
| Hydrochloric Acid SCHEMBL8949325 | 0.87 | ITGB3 (0.45) | ITGB3ITGA2B | |
| SCHEMBL8410914 | 0.82 | ITGB3 (0.42) | HRH3ITGB3ITGA2BPOLBALDH1A1 | |
| SCHEMBL8949271 | 0.82 | HTR2B (0.41) | ITGB3ITGA2BHTR2BMELK | |
| SCHEMBL8407952 | 0.80 | ITGB3 (0.49) | ITGB3ITGA2BPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL9568137 | 0.79 | HRH3 (0.39) | HRH3ITGB3ITGA2BHTR2BPOLB | |
| SCHEMBL9568130 | 0.79 | POLB (0.41) | HRH3ITGB3ITGA2BHTR2BPOLB | |
| SCHEMBL8409563 | 0.79 | SMN1; SMN2 (0.49) | HRH3HTR2BPOLBALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8949278 | 0.79 | ITGB3 (0.41) | ITGB3ITGA2B | |
| SCHEMBL9568214 | 0.79 | HRH3 (0.39) | HRH3ITGB3ITGA2BHTR2BPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563268-A | FOR PREVENTING CELL AGGLOMERATION, TREATING THROMBOSIS, ARTERIOSCLEROSIS, BRAIN, LUNG OR CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-10-08 | — | — | US | disclosed |
| US-5418233-A | FOR INHIBITING CELL AGGREGATION | KARL THOMAE GMBH (DE) | 1995-05-23 | — | — | US | disclosed |
| EP-0537696-A1 | Heterobiaryl derivatives, medicines containing those compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-04-21 | — | — | EP | disclosed |