Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 17/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 17/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8407957 | 0.91 | POLB (0.43) | ITGB3ITGA2BPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL8407358 | 0.87 | SMN1; SMN2 (0.54) | ITGB3ITGA2BPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL9568095 | 0.87 | TGM2 (0.48) | ITGB3ITGA2BPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL9568118 | 0.87 | POLB (0.45) | ITGB3ITGA2BPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL9568137 | 0.85 | HRH3 (0.39) | ITGB3ITGA2BPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL9568130 | 0.85 | POLB (0.41) | ITGB3ITGA2BPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL9568141 | 0.84 | POLB (0.43) | ITGB3ITGA2BPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL9568202 | 0.84 | POLB (0.43) | ITGB3ITGA2BPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL9568105 | 0.84 | ITGB3 (0.43) | ITGB3ITGA2BPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL9568089 | 0.84 | LMNA (0.41) | ITGB3ITGA2BPOLBALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922763-A | ANTICOAGULANT; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1999-07-13 | — | — | US | disclosed |
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |