Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ACP3 | P15309 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27991962 | 0.90 | POLB (0.45) | GAAPOLBALDH1A1SMN1; SMN2ACP3 | |
| SCHEMBL11459792 | 0.84 | ESR1 (0.38) | GAAALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL27991952 | 0.82 | POLB (0.47) | GAAPOLBALDH1A1SMN1; SMN2ACP3 | |
| SCHEMBL9659039 | 0.80 | NPSR1 (0.44) | POLBTDP1MEN1KMT2ANPSR1 | |
| SCHEMBL1246417 | 0.79 | ACP3 (0.62) | POLBACP3 | |
| SCHEMBL7540487 | 0.77 | TAAR1 (0.44) | GAAPOLBALDH1A1SMN1; SMN2ACP3 | |
| SCHEMBL6661383 | 0.77 | GAA (0.41) | GAAPOLBALDH1A1SMN1; SMN2TDP1 | |
| Ammonia Solution, Strong SCHEMBL11437728 | 0.75 | POLB (0.49) | POLBACP3NPSR1 | |
| SCHEMBL3696125 | 0.75 | ALDH1A1 (0.41) | GAAPOLBALDH1A1SMN1; SMN2ACP3 | |
| SCHEMBL11297491 | 0.73 | ACP3 (0.58) | ACP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5574024-A | Methylene phosphonoalkylphosphinates, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism | EBETINO FRANK H (US) | 1996-11-12 | — | — | US | disclosed |
| EP-0298553-B1 | METHYLENE PHOSPHONOALKYLPHOSPHINATES, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM | Norwich Eaton Pharmaceuticals, Inc. (US) | 1992-01-15 | — | — | EP | disclosed |
| EP-0298553-A1 | Methylene phosphonoalkylphosphinates, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism | Norwich Eaton Pharmaceuticals, Inc. (US) | 1989-01-11 | — | — | EP | disclosed |