Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 15/20 | 0.56 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | USP7 | Q93009 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6955413 | 0.87 | GCGR (0.49) | GCGRPRKAA2MEN1KMT2A | |
| SCHEMBL8949777 | 0.86 | GCGR (0.74) | GCGR | |
| SCHEMBL9263291 | 0.81 | GCGR (0.65) | GCGRNPC1RAB9A | |
| SCHEMBL6957028 | 0.79 | GCGR (0.50) | GCGRNPC1RAB9A | |
| SCHEMBL7557523 | 0.79 | GCGR (0.47) | GCGRDPP4 | |
| SCHEMBL2648588 | 0.78 | GCGR (0.86) | GCGR | |
| SCHEMBL6956576 | 0.77 | GCGR (0.46) | GCGRMEN1NPC1RAB9AKMT2A | |
| SCHEMBL8949822 | 0.77 | GCGR (0.88) | GCGR | |
| SCHEMBL10656158 | 0.77 | KDM4E (0.59) | GCGRPRKAA2 | |
| SCHEMBL2648917 | 0.75 | GCGR (0.86) | GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5502057-A | Polysubstituted pyridines useful for treating lipoproteinanaemia and arteriosclerosis | BAYER AKTIENGESELLSCHAFT (DE) | 1996-03-26 | — | — | US | disclosed |
| US-5470982-A | Disubstituted pyridines | BAYER AKTIENGESELLSCHAFT (DE) | 1995-11-28 | — | — | US | disclosed |
| EP-0325129-B1 | Disubstituted pyridines | BAYER AG (DE) | 1994-09-07 | — | — | EP | disclosed |
| US-5173495-A | 7-[(2,6-dialkyl-4-furyl or thienyl-pyridyl)]-3,5-di-(dihydroxy-6-enoates) useful for treating circulatory diseases | BAYER AKTIENGESELLSCHAFT (DE) | 1992-12-22 | — | — | US | disclosed |
| US-4968689-A | Certain 2,6-diisopropyl-4-(4-fluoro-phenyl)-3,5-bis-dimethyl-3',5'-dihydroxy-hept-6-enoate-pyridine derivatives useful for treating lipoproteinaemia and arteriosclerosis | BAYER AKTIENGESELLSCHAFT (DE) | 1990-11-06 | — | — | US | disclosed |
| CN-1034716-A | Disubstituted pyridines and preparation method thereof | BAYER AG (DE) | 1989-08-16 | — | — | CN | disclosed |
| EP-0325129-A2 | Disubstituted pyridines | BAYER AG (DE) | 1989-07-26 | — | — | EP | disclosed |