SCHEMBL8950683

SCHEMBL8950683

CCOC(=O)c1cc(Cl)c(Cl)c(Cl)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 3/20 0.60
CA1 P00915 3/20 0.60
CA2 P00918 3/20 0.60
CA7 P43166 3/20 0.60
CA9 Q16790 3/20 0.60
CA14 Q9ULX7 3/20 0.60
ESR1 P03372 2/20 0.53
ESR2 Q92731 1/20 0.50
MAPT P10636 1/20 0.49
PKM P14618 1/20 0.49
LMNA P02545 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
MAOA P21397 1/20 0.48
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
CYP4F2 P78329 1/20 0.46
CYP4A11 Q02928 1/20 0.46
BAZ2B Q9UIF8 1/20 0.46
BAZ2A Q9UIF9 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL691510 0.86 ESR1 (0.70) CA12CA1CA2CA7CA9
SCHEMBL31556327 0.85 CA12 (0.56) CA12CA1CA2CA7CA9
SCHEMBL9328767 0.85 CA12 (0.56) CA12CA1CA2CA7CA9
SCHEMBL6640579 0.85 CA12 (0.56) CA12CA1CA2CA7CA9
SCHEMBL3243690 0.83 ALDH1A1 (0.57) CA12CA1CA2CA7CA9
SCHEMBL1664013 0.83 CA12 (0.75) CA12CA1CA2CA7CA9
SCHEMBL6745027 0.82 ESR1 (0.59) CA12CA1CA2CA7CA9
SCHEMBL7304252 0.82 CA12 (0.53) CA12CA1CA2CA7CA9
SCHEMBL8856963 0.82 CA12 (0.53) CA12CA1CA2CA7CA9
SCHEMBL3595464 0.82 ESR1 (0.59) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5502073-A INSECTICIDES OR ANTHELMINTICS THE WELLCOME FOUNDATION (GB) 1996-03-26 US disclosed
EP-0296479-B1 Fluorobenzoates and process for their production IHARA CHEMICAL IND CO (JP) 1994-03-30 EP disclosed
EP-0294229-B1 NOVEL HETEROCYCLIC PESTICIDAL COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1992-12-02 EP disclosed
US-4916253-A Fluorobenzoates and process for their production IHARA CHEMICAL INDUSTRY COMPANY, LTD. (JP) 1990-04-10 US disclosed
EP-0296479-A2 Fluorobenzoates and process for their production IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) 1988-12-28 EP disclosed
EP-0294229-A2 Novel heterocyclic pesticidal compounds THE WELLCOME FOUNDATION LIMITED (GB) 1988-12-07 EP disclosed