Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | GPR3 | P46089 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30677836 | 0.77 | FFAR4 (0.37) | MPOGPR3FFAR4HTR1ADRD2 | |
| SCHEMBL13551133 | 0.75 | MPO (0.33) | MPOGPR3FFAR4HTR1ADRD2 | |
| SCHEMBL6264335 | 0.75 | AHR (0.45) | MPOGPR3FFAR4HTR1ADRD2 | |
| SCHEMBL29437972 | 0.75 | FFAR4 (0.34) | MPOGPR3FFAR4HTR1ADRD2 | |
| SCHEMBL423294 | 0.75 | ADORA2A (0.35) | MPOGPR3FFAR4HTR1ADRD2 | |
| SCHEMBL3151886 | 0.75 | FFAR4 (0.34) | MPOGPR3FFAR4HTR1ADRD2 | |
| SCHEMBL978248 | 0.75 | MPO (0.33) | MPOGPR3FFAR4HTR1ADRD2 | |
| SCHEMBL334653 | 0.75 | MPO (0.39) | MPOGPR3FFAR4HTR1ADRD2 | |
| SCHEMBL5325701 | 0.75 | MPO (0.33) | MPOGPR3FFAR4HTR1ADRD2 | |
| SCHEMBL10329924 | 0.75 | MPO (0.33) | MPOGPR3FFAR4HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5496848-A | Process for the preparation of substituted difluorobenzo-1,3-dioxoles | CIBA-GEIGY CORPORATION (US) | 1996-03-05 | — | — | US | claimed |
| EP-0333661-B1 | Process for the preparation of a pyrole derivative | CIBA GEIGY AG (CH) | 1994-04-27 | — | — | EP | claimed |
| EP-0333661-A2 | Process for the preparation of a pyrole derivative | CIBA-GEIGY AG (CH) | 1989-09-20 | — | — | EP | claimed |
| US-5514816-A | REACTION OF DIFLUOROBENZO-1,3-DIOXOLE WITH METAL COMPOUNDS FOR INSECTICIDES | CIBA-GEIGY CORPORATION (US) | 1996-05-07 | — | — | US | disclosed |
| US-5496848-A | Process for the preparation of substituted difluorobenzo-1,3-dioxoles | CIBA-GEIGY CORPORATION (US) | 1996-03-05 | — | — | US | disclosed |
| US-5493032-A | INSECTICIDES, MICROBIOCIDES | CIBA-GEIGY CORPORATION (US) | 1996-02-20 | — | — | US | disclosed |
| EP-0333658-B1 | Process for the preparation of substituted difluorbenzo-1,3-dioxoles | CIBA GEIGY AG (CH) | 1995-07-26 | — | — | EP | disclosed |
| US-5420301-A | Process for the preparation of substituted difluorobenzo-1,3-dioxoles | CIBA-GEIGY CORPORATION (US) | 1995-05-30 | — | — | US | disclosed |
| EP-0333661-B1 | Process for the preparation of a pyrole derivative | CIBA GEIGY AG (CH) | 1994-04-27 | — | — | EP | disclosed |
| US-5281718-A | Reacting in one pot reaction 2,2-difluorobenzodioxole with an organometal compound or metal to form 4-metallo-2,2-difluorobenzodioxole, reacting with unsaturated nitrile, then with isocyanide | CIBA-GEIGY CORPORATION (US) | 1994-01-25 | — | — | US | disclosed |
| US-5194628-A | Reacting metallo-difluorobenzodioxole with unsaturated nitrile and then with sulfonylmethyl isocyanide | CIBA-GEIGY CORPORATION (US) | 1993-03-16 | — | — | US | disclosed |
| EP-0333661-A2 | Process for the preparation of a pyrole derivative | CIBA-GEIGY AG (CH) | 1989-09-20 | — | — | EP | disclosed |
| EP-0333658-A2 | Process for the preparation of substituted difluorbenzo-1,3-dioxoles | CIBA-GEIGY AG (CH) | 1989-09-20 | — | — | EP | disclosed |