Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 7/20 | 0.50 |
| ▸ | EDNRB | P24530 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8906392 | 0.91 | EDNRB (0.52) | EDNRAEDNRB | |
| SCHEMBL8951969 | 0.89 | EDNRA (0.52) | EDNRAEDNRBKMT2AMEN1ALDH1A1 | |
| Potassium SCHEMBL8952100 | 0.89 | KMT2A (0.52) | EDNRAEDNRBKMT2AMEN1ALDH1A1 | |
| SCHEMBL8952097 | 0.89 | KMT2A (0.52) | EDNRAEDNRBKMT2AMEN1ALDH1A1 | |
| SCHEMBL8952137 | 0.87 | EDNRA (0.58) | EDNRAEDNRBKMT2AMEN1ALDH1A1 | |
| Potassium Ion SCHEMBL8952140 | 0.87 | KMT2A (0.52) | EDNRAEDNRBKMT2AMEN1ALDH1A1 | |
| SCHEMBL8952158 | 0.86 | EDNRA (0.53) | EDNRAEDNRBKMT2AMEN1ALDH1A1 | |
| SCHEMBL8952066 | 0.82 | EDNRA (0.51) | EDNRAEDNRBKMT2AMEN1ALDH1A1 | |
| Potassium SCHEMBL8951960 | 0.81 | EDNRA (0.47) | EDNRAEDNRBKMT2AMEN1ALDH1A1 | |
| SCHEMBL8951958 | 0.81 | EDNRA (0.47) | EDNRAEDNRBKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0710235-A4 | — | — | 1996-06-12 | — | — | EP | claimed |
| EP-0710235-A1 | ENDOTHELIN ANTAGONISTS | MERCK & CO. INC. (US) | 1996-05-08 | — | — | EP | claimed |