Potassium Ion

SCHEMBL8952140

CCCc1ccc(S(=O)(=O)NC(=O)C(Cc2ccc(C(=O)[O-])cc2)c2ccc3c(c2)OCO3)cc1.CCCc1ccc(S(=O)(=O)NC(=O)C(Cc2ccc(C(=O)[O-])cc2)c2ccc3c(c2)OCO3)cc1.[K+].[K+]

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

AGTR1 DHFR GABBR1 GABBR2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRE GABRG1 GABRG2 GABRG3 GABRP GABRQ GART NR3C2 PBP2X PTGS1 PTGS2 VKORC1 bla blaT-3 blaT-4 blaT-5 blaT-6 dacA dacB dacC folA ftsI mrcA mrcB mrdA pbp1a pbp1b pbp2a pbp2b pbp3 pol thyA

The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 7)

	gene	UniProt	supporting neighbours	confidence
▸	KMT2A	Q03164	3/20	0.52

▸	MEN1	O00255	2/20	0.52

▸	EDNRA	P25101	9/20	0.52

▸	EDNRB	P24530	8/20	0.52

▸	ALDH1A1	P00352	2/20	0.44

▸	LMNA	P02545	2/20	0.44

▸	SMN1; SMN2	Q16637	1/20	0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL8952137	0.91	EDNRA (0.58)	KMT2AMEN1EDNRAEDNRBALDH1A1
Potassium Ion SCHEMBL8907336	0.91	EDNRA (0.53)	EDNRAEDNRB
SCHEMBL8952158	0.90	EDNRA (0.53)	KMT2AMEN1EDNRAEDNRBALDH1A1
SCHEMBL8951969	0.90	EDNRA (0.52)	KMT2AMEN1EDNRAEDNRBALDH1A1
SCHEMBL8952097	0.90	KMT2A (0.52)	KMT2AMEN1EDNRAEDNRBALDH1A1
Potassium SCHEMBL8952100	0.90	KMT2A (0.52)	KMT2AMEN1EDNRAEDNRBALDH1A1
SCHEMBL8952113	0.87	EDNRA (0.50)	KMT2AMEN1EDNRAEDNRBALDH1A1
SCHEMBL8952066	0.83	EDNRA (0.51)	KMT2AMEN1EDNRAEDNRBALDH1A1
Potassium SCHEMBL8951960	0.82	EDNRA (0.47)	KMT2AMEN1EDNRAEDNRBALDH1A1
SCHEMBL8951958	0.82	EDNRA (0.47)	KMT2AMEN1EDNRAEDNRBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0710235-A4	—	—	1996-06-12	—	—	EP	claimed
EP-0710235-A1	ENDOTHELIN ANTAGONISTS	MERCK & CO. INC. (US)	1996-05-08	—	—	EP	claimed
WO-1995003295-A1	ENDOTHELIN ANTAGONISTS	MERCK & CO., INC. (US)	1995-02-02	—	—	WO	claimed