Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438390 | 0.84 | SIGMAR1 (0.49) | EPHX2SIGMAR1KMT2AGRIN2DGRIN3B | |
| SCHEMBL7438385 | 0.84 | SIGMAR1 (0.49) | EPHX2SIGMAR1KMT2AGRIN2DGRIN3B | |
| SCHEMBL6158188 | 0.83 | SIGMAR1 (0.50) | EPHX2SIGMAR1KMT2AGRIN2DGRIN3B | |
| SCHEMBL8952148 | 0.79 | EPHX2 (0.49) | EPHX2KMT2AHSD11B1CNR1CNR2 | |
| SCHEMBL7492189 | 0.74 | SIGMAR1 (0.46) | EPHX2SIGMAR1KMT2ACNR2 | |
| SCHEMBL6155006 | 0.69 | SIGMAR1 (0.50) | EPHX2SIGMAR1KMT2AGRIN2DGRIN3B | |
| SCHEMBL7441850 | 0.68 | MEN1 (0.48) | EPHX2SIGMAR1KMT2AGRIN2DGRIN3B | |
| SCHEMBL15359829 | 0.67 | SIGMAR1 (0.44) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6158181 | 0.67 | SIGMAR1 (0.53) | EPHX2SIGMAR1KMT2AHSD11B1 | |
| SCHEMBL8873648 | 0.66 | SIGMAR1 (0.49) | EPHX2SIGMAR1GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5552443-A | TREATMENT OF PSYCHOSIS, ANXIETY AND AS HYPOTENSIVE AGENTS | OREGON HEALTH SCIENCES UNIVERSITY (US) | 1996-09-03 | — | — | US | disclosed |
| US-5308869-A | TREATMENT OR PROPHYLAXIS OF ANXIETY IN AN ANIMAL | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION (US) | 1994-05-03 | — | — | US | disclosed |