SCHEMBL8952925

SCHEMBL8952925

C=C(CO[PH](=O)CC(CC(=O)O)O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)c1c(C2CC2)nc(-c2ccccc2)c(C)c1-c1ccc(F)cc1

nearest known ligand 0.42

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
NR1I2 O75469 1/20 0.33
NR4A2 P43354 1/20 0.33
PDE4D Q08499 1/20 0.33
PRKAA2 P54646 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8952921 1.00 NR1I2 (0.33) NR1I2NR4A2PDE4DPRKAA2
SCHEMBL8952891 0.86 NR1I2 (0.42) NR1I2NR4A2PDE4DPRKAA2
SCHEMBL8952880 0.86 NR1I2 (0.42) NR1I2NR4A2PDE4DPRKAA2
SCHEMBL8952816 0.85 NR1I2 (0.33) NR1I2NR4A2PDE4DPRKAA2
SCHEMBL8952821 0.85 NR1I2 (0.33) NR1I2NR4A2PDE4DPRKAA2
SCHEMBL8952914 0.82 NR1I2 (0.33) NR1I2NR4A2PDE4DPRKAA2
SCHEMBL8952855 0.75
SCHEMBL8952791 0.75 HMGCR (0.37) NR1I2PDE4D
SCHEMBL8953323 0.75
SCHEMBL8952741 0.75 FABP4 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5506219-A ANTICHOLESTEROL AND ANTILIPEMIC AGENTS E. R. SQUIBB & SONS, INC. (US) 1996-04-09 US disclosed