Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8952973 | 1.00 | HMGCR (0.49) | HMGCR | |
| SCHEMBL8952665 | 0.89 | HMGCR (0.49) | HMGCR | |
| SCHEMBL8952672 | 0.89 | HMGCR (0.49) | HMGCR | |
| SCHEMBL8952710 | 0.85 | — | — | |
| SCHEMBL8952714 | 0.85 | — | — | |
| SCHEMBL8952910 | 0.85 | HMGCR (0.40) | HMGCR | |
| SCHEMBL8952755 | 0.83 | — | — | |
| SCHEMBL9550566 | 0.83 | — | — | |
| SCHEMBL9562779 | 0.83 | — | — | |
| SCHEMBL8953327 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5506219-A | ANTICHOLESTEROL AND ANTILIPEMIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0356788-A2 | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1990-03-07 | — | — | EP | disclosed |