SCHEMBL8953137

SCHEMBL8953137

COP(=O)(C#Cc1c(C(C)C)nc2c(c1-c1ccc(F)cc1)Cc1ccccc1-2)C[C@H](CC(=O)O)O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C

nearest known ligand 0.57

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SQOR Q9Y6N5 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9849211 0.94 SQOR (0.34) SQOR
SCHEMBL8952784 0.94 SQOR (0.34) SQOR
SCHEMBL8953003 0.88
SCHEMBL8952839 0.87
SCHEMBL8952852 0.87
SCHEMBL8952983 0.86 SQOR (0.46) SQOR
SCHEMBL8952940 0.86
SCHEMBL8952835 0.85
SCHEMBL8953142 0.83 SQOR (0.39) SQOR
SCHEMBL8953147 0.83 SQOR (0.39) SQOR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5506219-A ANTICHOLESTEROL AND ANTILIPEMIC AGENTS E. R. SQUIBB & SONS, INC. (US) 1996-04-09 US disclosed
EP-0444533-A2 Quinoline and pyridine anchors for HMG-CoA reductase inhibitors E.R. SQUIBB & SONS, INC. (US) 1991-09-04 EP disclosed