Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.64 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.64 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.64 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | MARS1 | P56192 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8953954 | 0.87 | RXRA (0.82) | RXRANR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL8635490 | 0.84 | PTGS2 (0.80) | PTGS2PTGS1CYP2C9PDPK1 | |
| SCHEMBL8953923 | 0.84 | PTGS2 (0.80) | PTGS2PTGS1CYP2C9PDPK1 | |
| SCHEMBL15641669 | 0.80 | RXRA (0.82) | RXRANR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL7878995 | 0.78 | PTGS2 (0.73) | PTGS2PTGS1CYP2C9PDPK1 | |
| SCHEMBL7876231 | 0.78 | PTGS2 (0.73) | PTGS2PTGS1CYP2C9PDPK1 | |
| SCHEMBL6167641 | 0.78 | — | — | |
| SCHEMBL6735880 | 0.78 | PTGS2 (0.57) | RXRANR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL3474679 | 0.78 | RXRA (1.00) | RXRANR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL8636647 | 0.77 | PTGS2 (1.00) | PTGS2PTGS1CYP2C9PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731794-A1 | 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS | SEARLE & CO (US) | 1996-09-18 | — | — | EP | disclosed |
| WO-1995015317-A1 | 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS | G.D. SEARLE & CO. (US) | 1995-06-08 | — | — | WO | disclosed |