Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.37 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8954128 | 0.86 | ALDH1A1 (0.40) | ALDH1A1HSD17B10TP53CYP1A2CYP3A4 | |
| SCHEMBL8954119 | 0.79 | TP53 (0.41) | ALDH1A1HSD17B10TP53 | |
| SCHEMBL8954287 | 0.78 | ALDH1A1 (0.40) | ALDH1A1HSD17B10TP53 | |
| SCHEMBL8954183 | 0.78 | TP53 (0.42) | ALDH1A1HSD17B10TP53 | |
| SCHEMBL8954200 | 0.76 | ALDH1A1 (0.45) | ALDH1A1HSD17B10TP53CYP1A2CYP3A4 | |
| SCHEMBL8954114 | 0.76 | TP53 (0.47) | ALDH1A1HSD17B10TP53 | |
| SCHEMBL8954242 | 0.76 | ALDH1A1 (0.44) | ALDH1A1HSD17B10TP53CYP1A2CYP3A4 | |
| SCHEMBL9473192 | 0.75 | CCR2 (0.45) | ALDH1A1HSD17B10TP53 | |
| SCHEMBL8954176 | 0.74 | TP53 (0.42) | TP53 | |
| SCHEMBL8954069 | 0.74 | TP53 (0.40) | ALDH1A1HSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530017-A | CONGESTIVE HEART FAILURE, RENAL FAILURE AND GLAUCOMA | SMITHKLINE BEECHAM CORP (US) | 1996-06-25 | — | — | US | disclosed |
| US-5444080-A | Hypotensive agents | SMITHKLINE BEECHAM CORPORATION (US) | 1995-08-22 | — | — | US | disclosed |
| EP-0541705-A4 | SUBSTITUTED 1H-IMIDAZOL-5-YL)ALKANOIC ACIDS | — | 1993-11-10 | — | — | EP | disclosed |
| EP-0541705-A1 | SUBSTITUTED 1H-IMIDAZOL-5-YL]ALKANOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-05-19 | — | — | EP | disclosed |
| WO-1992002510-A1 | SUBSTITUTED [1H-IMIDAZOL-5-YL]ALKANOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-02-20 | — | — | WO | disclosed |