Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KLK7 | P49862 | 4/20 | 0.35 |
| ▸ | KLK5 | Q9Y337 | 4/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8954218 | 1.00 | TLR7 (0.36) | TLR7L3MBTL1KLK7KLK5PRSS1 | |
| SCHEMBL8954215 | 1.00 | TLR7 (0.36) | TLR7L3MBTL1KLK7KLK5PRSS1 | |
| SCHEMBL7975881 | 0.70 | MEN1 (0.35) | TLR7L3MBTL1PDE10A | |
| SCHEMBL7986647 | 0.69 | MEN1 (0.37) | TLR7L3MBTL1PDE10A | |
| SCHEMBL7987345 | 0.69 | L3MBTL1 (0.33) | TLR7L3MBTL1PDE10A | |
| SCHEMBL10441676 | 0.68 | KMT2A (0.34) | TLR7L3MBTL1PDE10A | |
| SCHEMBL9424439 | 0.68 | KMT2A (0.34) | TLR7L3MBTL1PDE10A | |
| SCHEMBL7395406 | 0.68 | HDAC3 (0.41) | TLR7L3MBTL1PDE10A | |
| SCHEMBL7990760 | 0.67 | L3MBTL1 (0.33) | TLR7L3MBTL1PDE10AGPR119 | |
| SCHEMBL7402017 | 0.67 | HDAC3 (0.40) | TLR7L3MBTL1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530017-A | CONGESTIVE HEART FAILURE, RENAL FAILURE AND GLAUCOMA | SMITHKLINE BEECHAM CORP (US) | 1996-06-25 | — | — | US | disclosed |
| US-5444080-A | Hypotensive agents | SMITHKLINE BEECHAM CORPORATION (US) | 1995-08-22 | — | — | US | disclosed |
| EP-0541705-A4 | SUBSTITUTED 1H-IMIDAZOL-5-YL)ALKANOIC ACIDS | — | 1993-11-10 | — | — | EP | disclosed |
| EP-0541705-A1 | SUBSTITUTED 1H-IMIDAZOL-5-YL]ALKANOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-05-19 | — | — | EP | disclosed |
| WO-1992002510-A1 | SUBSTITUTED [1H-IMIDAZOL-5-YL]ALKANOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-02-20 | — | — | WO | disclosed |