Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 5/20 | 0.57 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.55 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.47 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8954223 | 0.88 | AGTR1 (0.62) | AGTR1AGTR2 | |
| SCHEMBL8954110 | 0.87 | AGTR1 (0.61) | AGTR1AGTR2 | |
| SCHEMBL8954159 | 0.85 | AGTR1 (0.61) | AGTR1AGTR2ABCC3ABCC2 | |
| SCHEMBL8954239 | 0.84 | AGTR1 (0.58) | AGTR1 | |
| SCHEMBL8954090 | 0.84 | AGTR1 (0.57) | AGTR1AGTR2 | |
| SCHEMBL8954212 | 0.82 | AGTR1 (0.53) | AGTR1AGTR2 | |
| SCHEMBL8954036 | 0.81 | AGTR1 (0.52) | AGTR1 | |
| SCHEMBL8954246 | 0.81 | AGTR1 (0.56) | AGTR1ABCC3ABCC2 | |
| SCHEMBL9386724 | 0.81 | AGTR1 (0.65) | AGTR1 | |
| SCHEMBL8434040 | 0.81 | AGTR1 (0.65) | AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530017-A | CONGESTIVE HEART FAILURE, RENAL FAILURE AND GLAUCOMA | SMITHKLINE BEECHAM CORP (US) | 1996-06-25 | — | — | US | disclosed |
| US-5444080-A | Hypotensive agents | SMITHKLINE BEECHAM CORPORATION (US) | 1995-08-22 | — | — | US | disclosed |
| EP-0541705-A4 | SUBSTITUTED 1H-IMIDAZOL-5-YL)ALKANOIC ACIDS | — | 1993-11-10 | — | — | EP | disclosed |
| EP-0541705-A1 | SUBSTITUTED 1H-IMIDAZOL-5-YL]ALKANOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-05-19 | — | — | EP | disclosed |
| WO-1992002510-A1 | SUBSTITUTED [1H-IMIDAZOL-5-YL]ALKANOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-02-20 | — | — | WO | disclosed |