⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL52748 | 0.74 | — | — | |
| SCHEMBL1374067 | 0.74 | — | — | |
| SCHEMBL8630963 | 0.70 | — | — | |
| SCHEMBL1876585 | 0.70 | — | — | |
| SCHEMBL5675312 | 0.70 | — | — | |
| SCHEMBL7955941 | 0.70 | — | — | |
| SCHEMBL29002084 | 0.70 | — | — | |
| SCHEMBL3290131 | 0.67 | — | — | |
| SCHEMBL1679882 | 0.67 | — | — | |
| SCHEMBL797162 | 0.67 | ALDH1A1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786308-B2 | Muscarinic modulators | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-08-31 | — | — | US | claimed |
| US-20080090826-A9 | Muscarinic modulators | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC | 2008-04-17 | — | — | US | claimed |
| EP-1863490-A2 | MUSCARINIC MODULATORS | Vertex Pharmaceuticals Incorporated (US) | 2007-12-12 | — | — | EP | claimed |
| US-20070054911-A1 | Muscarinic modulators | VERTEX PHARMACEUTICALS INCORPORATED | 2007-03-08 | — | — | US | claimed |
| WO-2006105035-A2 | MUSCARINIC MODULATORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-10-05 | — | — | WO | claimed |
| US-20240216357-A1 | POLYCYCLIC COMPOUND AND APPLICATION THEREOF | SICHUAN HUIYU PHARMACEUTICAL CO., LTD. (CN) | 2024-07-04 | — | — | US | disclosed |
| CN-117062813-A | Polycyclic compound and application thereof | 四川汇宇制药股份有限公司 | 2023-11-14 | — | — | CN | disclosed |
| US-20200231550-A1 | COMPOUNDS FOR TREATING TUBERCULOSIS | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2020-07-23 | — | — | US | disclosed |
| CN-111433205-A | Polycyclic compounds as allosteric SHP2 inhibitors | 锐新医药公司 | 2020-07-17 | — | — | CN | disclosed |
| US-8598176-B2 | Pyridazine compound and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-12-03 | — | — | US | disclosed |
| US-8258136-B2 | Pyridazine compound and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-09-04 | — | — | US | disclosed |
| CN-101326176-B | Pyridazine compound and use thereof | SUMITOMO CHEMICAL CO | 2012-05-30 | — | — | CN | disclosed |
| US-20050239790-A1 | Substituted hydroxyethylamine aspartyl protease inhibitors | ELAN PHARMACEUTICALS, INC. | 2005-10-27 | — | — | US | disclosed |
| WO-2005087752-A2 | SUBSTITUTED HYDROXYETHYLAMINE ASPARTYL PROTEASE INHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 2005-09-22 | — | — | WO | disclosed |
| WO-2005087751-A2 | SUBSTITUTED HYDROXYETHYLAMINE ASPARTYL PROTEASE INHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 2005-09-22 | — | — | WO | disclosed |
| US-6884802-B2 | 6-heteroarylphenanthridines | ALTANA PHARMA AG (DE) | 2005-04-26 | — | — | US | disclosed |
| WO-2005012252-A1 | NOVEL 6-PHENYLPHENANTRIDINES | ALTANA PHARMA AG (DE) | 2005-02-10 | — | — | WO | disclosed |
| US-20040038979-A1 | Treating airway disorders such as asthma. | ALTANA PHARMA AG (DE) | 2004-02-26 | — | — | US | disclosed |
| EP-1303506-A1 | 6-HETEROARYLPHENANTHRIDINES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002006270-A1 | NOVEL 6-HETEROARYLPHENANTHRIDINES | ALTANA PHARMA AG (DE) | 2002-01-24 | — | — | WO | disclosed |