Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 13/20 | 0.53 |
| ▸ | PLAU | P00749 | 6/20 | 0.51 |
| ▸ | PLG | P00747 | 9/20 | 0.50 |
| ▸ | ST14 | Q9Y5Y6 | 7/20 | 0.50 |
| ▸ | F2 | P00734 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HPN | P05981 | 1/20 | 0.46 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8956082 | 0.99 | F10 (0.54) | F10PLAUPLGST14F2 | |
| SCHEMBL8956272 | 0.85 | GAA (0.48) | GAAMAPTNPSR1 | |
| Iodide SCHEMBL8955189 | 0.77 | F10 (0.43) | F10PLAUPLGST14F2 | |
| SCHEMBL8956093 | 0.76 | F10 (0.44) | F10PLAUPLGST14F2 | |
| SCHEMBL8954659 | 0.73 | MAPT (0.46) | GAAMAPTNPSR1 | |
| SCHEMBL30583119 | 0.72 | F10 (0.76) | F10PLAUPLGST14F2 | |
| SCHEMBL8955017 | 0.71 | F10 (0.69) | F10PLAUPLGST14F2 | |
| SCHEMBL8954726 | 0.70 | F10 (0.75) | F10PLAUPLGST14F2 | |
| SCHEMBL8954681 | 0.70 | F10 (0.75) | F10PLAUPLGST14F2 | |
| SCHEMBL8954768 | 0.70 | F10 (0.75) | F10PLAUPLGST14F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5518735-A | ANTICOAGULANTS ADMINISTERED BY MOUTH | PENTAPHARM AG (CH) | 1996-05-21 | — | — | US | disclosed |