Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Galactose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | TOP1 | P11387 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demannose SCHEMBL16879734 | 1.00 | LMNA (0.44) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Galactose SCHEMBL8954978 | 1.00 | LMNA (0.44) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Demannose SCHEMBL8211932 | 0.96 | LMNA (0.41) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Demannose SCHEMBL15054273 | 0.96 | LMNA (0.41) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Demannose SCHEMBL14248791 | 0.94 | PDE4A (0.42) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Demannose SCHEMBL743641 | 0.94 | LMNA (0.46) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Demannose SCHEMBL8648968 | 0.94 | LMNA (0.46) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Demannose SCHEMBL8910520 | 0.94 | LMNA (0.50) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Demannose SCHEMBL936579 | 0.94 | LMNA (0.50) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Demannose SCHEMBL329074 | 0.94 | LMNA (0.50) | LMNAL3MBTL1TDP1KDM4EPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541098-A | Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells | SANOFI (FR) | 1996-07-30 | — | — | US | disclosed |
| US-5407822-A | Artificial promoter for the expression of proteins in yeast | SANOFI (FR) | 1995-04-18 | — | — | US | disclosed |
| US-5382518-A | Proteins | SANOFI (FR) | 1995-01-17 | — | — | US | disclosed |