Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 2/20 | 0.42 |
| ▸ | CASR | P41180 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27904038 | 1.00 | TDP1 (0.67) | TDP1CYP1A2CYP2D6CYP2C19TP53 | |
| SCHEMBL10359841 | 0.87 | TSHR (0.68) | TDP1CYP1A2CYP2D6CYP2C19TP53 | |
| SCHEMBL8956162 | 0.85 | L3MBTL1 (0.57) | TDP1CYP1A2CYP2D6CYP2C19TP53 | |
| SCHEMBL8955369 | 0.84 | TP53 (0.47) | TDP1CYP1A2CYP2D6CYP2C19TP53 | |
| SCHEMBL7968991 | 0.82 | TDP1 (0.54) | TDP1CYP1A2CYP2D6CYP2C19TP53 | |
| SCHEMBL8778502 | 0.82 | TDP1 (0.54) | TDP1CYP1A2CYP2D6CYP2C19TP53 | |
| SCHEMBL11441977 | 0.81 | TP53 (0.49) | TDP1CYP1A2CYP2D6CYP2C19TP53 | |
| SCHEMBL8297330 | 0.80 | TSHR (1.00) | TDP1CYP1A2CYP2D6CYP2C19TP53 | |
| SCHEMBL29516806 | 0.80 | TSHR (1.00) | TDP1CYP1A2CYP2D6CYP2C19TP53 | |
| SCHEMBL2205558 | 0.80 | TDP1 (0.55) | TDP1CYP1A2CYP2D6CYP2C19TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516767-A | PRODRUG AS HYPOGLYCEMIC AGENT | SANDOZ LTD. (CH) | 1996-05-14 | — | — | US | disclosed |
| US-5412137-A | Hypoglycemic agents | SANDOZ LTD. (CH) | 1995-05-02 | — | — | US | disclosed |