Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.53 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11567245 | 1.00 | HRH3 (0.53) | HRH3ALDH3A1LMNAALDH1A1KCNH2 | |
| SCHEMBL8955454 | 1.00 | HRH3 (0.53) | HRH3ALDH3A1LMNAALDH1A1KCNH2 | |
| SCHEMBL10384992 | 1.00 | HRH3 (0.53) | HRH3ALDH3A1LMNAALDH1A1KCNH2 | |
| SCHEMBL8955525 | 1.00 | HRH3 (0.53) | HRH3ALDH3A1LMNAALDH1A1KCNH2 | |
| SCHEMBL7862630 | 1.00 | HRH3 (0.53) | HRH3ALDH3A1LMNAALDH1A1KCNH2 | |
| SCHEMBL8956151 | 1.00 | HRH3 (0.53) | HRH3ALDH3A1LMNAALDH1A1KCNH2 | |
| SCHEMBL11442484 | 0.98 | ALDH3A1 (0.53) | HRH3ALDH3A1LMNAALDH1A1KCNH2 | |
| SCHEMBL4383977 | 0.91 | DRD4 (0.52) | HRH3ALDH3A1LMNAALDH1A1KCNH2 | |
| SCHEMBL10999277 | 0.89 | LMNA (0.54) | HRH3ALDH3A1LMNAALDH1A1KCNH2 | |
| SCHEMBL30514014 | 0.89 | HRH3 (0.61) | HRH3ALDH3A1ALDH1A1KCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516767-A | PRODRUG AS HYPOGLYCEMIC AGENT | SANDOZ LTD. (CH) | 1996-05-14 | — | — | US | disclosed |
| US-5412137-A | Hypoglycemic agents | SANDOZ LTD. (CH) | 1995-05-02 | — | — | US | disclosed |