Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CETP | P11597 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8370558 | 0.90 | PIM1 (0.48) | HDAC1HDAC2PDK2PIM1 | |
| SCHEMBL8955822 | 0.88 | PDK2 (0.49) | HDAC1HDAC2PDK2PIM1 | |
| SCHEMBL8955539 | 0.88 | HDAC1 (0.50) | HDAC1HDAC2PDK2MRGPRX4 | |
| SCHEMBL31466611 | 0.85 | PIM1 (0.52) | HDAC1HDAC2PDK2PIM1 | |
| SCHEMBL2095220 | 0.85 | PIM1 (0.52) | HDAC1HDAC2PDK2PIM1 | |
| SCHEMBL8778594 | 0.84 | TSHR (0.42) | HDAC1HDAC2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8955470 | 0.81 | PDK2 (0.47) | HDAC1HDAC2PDK2 | |
| SCHEMBL13750033 | 0.81 | PDK2 (0.47) | HDAC1HDAC2PDK2 | |
| SCHEMBL2090929 | 0.81 | PDK2 (0.47) | HDAC1HDAC2PDK2 | |
| SCHEMBL2097585 | 0.80 | ALDH1A1 (0.52) | HDAC1HDAC2PDK2ALDH1A1CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516767-A | PRODRUG AS HYPOGLYCEMIC AGENT | SANDOZ LTD. (CH) | 1996-05-14 | — | — | US | disclosed |
| US-5412137-A | Hypoglycemic agents | SANDOZ LTD. (CH) | 1995-05-02 | — | — | US | disclosed |