SCHEMBL8955867

SCHEMBL8955867

CSC(CCc1ccc(C(C)(C)C)cc1)Cn1ccnc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.51
LMNA P02545 1/20 0.51
TP53 P04637 1/20 0.51
CYP1A2 P05177 1/20 0.51
CYP3A4 P08684 1/20 0.51
CYP2D6 P10635 1/20 0.51
CYP2C9 P11712 1/20 0.51
ALOX15 P16050 1/20 0.51
TSHR P16473 1/20 0.51
CYP2C19 P33261 1/20 0.51
HIF1A Q16665 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
NR1I2 O75469 1/20 0.51
ESR1 P03372 1/20 0.51
NR3C1 P04150 1/20 0.51
PGR P06401 1/20 0.51
ADORA3 P0DMS8 1/20 0.51
ADRA2B P18089 1/20 0.51
CHRM3 P20309 1/20 0.51
AGTR1 P30556 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8955833 0.87 CYP19A1 (0.48) ALDH1A1LMNATP53CYP1A2CYP3A4
SCHEMBL11635141 0.83 CYP1A2 (0.64) ALDH1A1LMNATP53CYP1A2CYP3A4
SCHEMBL11069974 0.82 IDO1 (0.50) ALDH1A1LMNATP53CYP1A2CYP3A4
SCHEMBL10926345 0.82 IDO1 (0.47) IDO1MEN1POLBKMT2ACYP19A1
SCHEMBL11464897 0.80 ALDH1A1 (0.52) ALDH1A1LMNATP53CYP1A2CYP3A4
SCHEMBL11736925 0.79 IDO1 (0.45) ALDH1A1LMNATP53CYP1A2CYP3A4
SCHEMBL8956242 0.78 ALDH1A1 (0.39) ALDH1A1CYP3A4PDE4DCYP19A1
SCHEMBL10925829 0.75 IDO1 (0.45) ALDH1A1LMNAIDO1MEN1POLB
SCHEMBL11632437 0.75 CYP3A4 (0.49) ALDH1A1LMNATP53CYP1A2CYP3A4
SCHEMBL11015773 0.75 CYP19A1 (0.51) TP53TSHRIDO1MEN1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5486533-A DIAZOLE OR TRIAZOLES WITH SILFIDES UNIROYAL CHEMICAL COMPANY, INC. (US) 1996-01-23 US disclosed
WO-1994008978-A1 FUNGICIDAL SUBSTITUTED AZOLE DERIVATIVES UNIROYAL CHEMICAL COMPANY, INC. (US) 1994-04-28 WO disclosed