SCHEMBL8955897

SCHEMBL8955897

C=CCCc1ccc(C(C)(C)C)cc1

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.47
TSHR P16473 2/20 0.43
TP53 P04637 1/20 0.43
SIGMAR1 Q99720 5/20 0.42
GPR84 Q9NQS5 1/20 0.41
GRIA4 P48058 1/20 0.41
ESRRG P62508 4/20 0.40
SLC13A5 Q86YT5 2/20 0.40
DAO P14920 1/20 0.40
ESRRB O95718 2/20 0.39
BCHE P06276 1/20 0.38
ACHE P22303 1/20 0.38
LMNA P02545 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8956085 0.88 KCNH2 (0.53) KCNH2TSHRTP53SIGMAR1GPR84
SCHEMBL9197909 0.82 ESR1 (0.44) KCNH2TSHRGRIA4
SCHEMBL9004469 0.82 GFER (0.36) TSHRTP53BCHEACHE
SCHEMBL6285109 0.79 GFER (0.41) TSHRTP53BCHEACHE
SCHEMBL7456580 0.79 KCNH2 (0.59) KCNH2TSHRTP53SIGMAR1GPR84
SCHEMBL1612731 0.79 KCNH2 (0.47) KCNH2TSHRTP53SIGMAR1GPR84
SCHEMBL1864936 0.79 TP53 (0.52) KCNH2TSHRTP53SIGMAR1GPR84
SCHEMBL66122 0.79 TP53 (0.52) KCNH2TSHRTP53SIGMAR1GPR84
SCHEMBL8803722 0.79 TAAR1 (0.55) DAO
SCHEMBL8955799 0.78 ALDH1A1 (0.52) KCNH2TSHRTP53BCHEACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115141073-B Preparation method of aromatic hydrocarbon dimer compound 五邑大学 2024-05-24 CN disclosed
CN-115724706-B Method for rapidly converting aldehyde group into cyano group 中国科学院兰州化学物理研究所 2024-04-12 CN disclosed
CN-117486772-A Preparation method of 1, 2-diselenide compound 中国石油大学(华东) 2024-02-02 CN disclosed
CN-115724706-A Method for quickly converting aldehyde group into cyano group 中国科学院兰州化学物理研究所 2023-03-03 CN disclosed
CN-115141073-A Preparation method of aromatic hydrocarbon dimer compound 五邑大学 2022-10-04 CN disclosed
CN-111116285-B Efficient preparation method of 1-aryl-4-butene compound 大连理工大学 2021-05-07 CN disclosed
CN-111116285-A Efficient preparation method of 1-aryl-4-butene compound 大连理工大学 2020-05-08 CN disclosed
US-5486533-A DIAZOLE OR TRIAZOLES WITH SILFIDES UNIROYAL CHEMICAL COMPANY, INC. (US) 1996-01-23 US disclosed
EP-0663904-A1 FUNGICIDAL SUBSTITUTED AZOLE DERIVATIVES UNIROYAL CHEMICAL COMPANY, Inc. (US) 1995-07-26 EP disclosed
WO-1994008978-A1 FUNGICIDAL SUBSTITUTED AZOLE DERIVATIVES UNIROYAL CHEMICAL COMPANY, INC. (US) 1994-04-28 WO disclosed