Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 5/20 | 0.39 |
| ▸ | MME | P08473 | 3/20 | 0.39 |
| ▸ | CPA1 | P15085 | 3/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.39 |
| ▸ | MMP2 | P08253 | 13/20 | 0.38 |
| ▸ | MMP3 | P08254 | 9/20 | 0.38 |
| ▸ | MMP1 | P03956 | 8/20 | 0.38 |
| ▸ | MMP7 | P09237 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8957141 | 0.96 | ACE (0.42) | ACEMMECPA1ACE2MMP2 | |
| SCHEMBL8971441 | 0.93 | ACE (0.40) | ACEMMECPA1ACE2 | |
| SCHEMBL8957278 | 0.84 | ACE (0.40) | ACEMMECPA1ACE2 | |
| SCHEMBL8957110 | 0.83 | MME (0.35) | ACEMMECPA1ACE2 | |
| SCHEMBL8971512 | 0.83 | ACE (0.37) | ACEMMECPA1ACE2 | |
| SCHEMBL8957204 | 0.81 | ACE (0.42) | ACEMMECPA1ACE2MMP2 | |
| SCHEMBL8957132 | 0.80 | HCAR3 (0.38) | MME | |
| SCHEMBL8957264 | 0.80 | ACE (0.37) | ACEMMECPA1ACE2 | |
| SCHEMBL7049829 | 0.79 | MME (0.41) | ACEMMECPA1ACE2 | |
| SCHEMBL8957142 | 0.78 | MME (0.36) | ACEMMECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5565480-A | ANGIOTENSIN II RECEPTOR ANTAGONIST; USEFUL IN REGULATING HYPERTENSION, TREATMENT OF CONGESTIVE HEART FAILURE, RENAL FAILURE AND GLUCOMA | SMITHKLINE BEECHAM CORPORATION (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0536262-A4 | SUBSTITUTED HISTIDINES | SMITHKLINE BEECHAM CORP (US) | 1996-08-14 | — | — | EP | disclosed |
| US-5444081-A | Treatment of hypertension, congestive heart failure, renal failure, glaucoma | SMITHKLINE BEECHAM CORP (US) | 1995-08-22 | — | — | US | disclosed |
| EP-0536262-A1 | SUBSTITUTED HISTIDINES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1992000068-A1 | SUBSTITUTED HISTIDINES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-09 | — | — | WO | disclosed |