Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 18/20 | 0.37 |
| ▸ | MME | P08473 | 14/20 | 0.37 |
| ▸ | CPA1 | P15085 | 14/20 | 0.37 |
| ▸ | ACE2 | Q9BYF1 | 14/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8971441 | 0.83 | ACE (0.40) | ACEMMECPA1ACE2 | |
| SCHEMBL8957141 | 0.81 | ACE (0.42) | ACEMMECPA1ACE2 | |
| SCHEMBL8957107 | 0.80 | ACE (0.39) | ACEMMECPA1ACE2 | |
| SCHEMBL8896490 | 0.74 | ACE (0.41) | ACEMMECPA1ACE2 | |
| SCHEMBL10826319 | 0.73 | CYP3A4 (0.49) | ACEMMECPA1ACE2 | |
| SCHEMBL10826470 | 0.73 | ACE (0.49) | ACEMMECPA1ACE2 | |
| SCHEMBL29071842 | 0.73 | ACE (0.38) | ACEMMECPA1ACE2 | |
| SCHEMBL10826528 | 0.72 | MME (0.52) | ACEMME | |
| SCHEMBL17293240 | 0.72 | CTRB1 (0.37) | ACEMMECPA1ACE2 | |
| SCHEMBL3916119 | 0.72 | CTRB1 (0.37) | ACEMMECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5565480-A | ANGIOTENSIN II RECEPTOR ANTAGONIST; USEFUL IN REGULATING HYPERTENSION, TREATMENT OF CONGESTIVE HEART FAILURE, RENAL FAILURE AND GLUCOMA | SMITHKLINE BEECHAM CORPORATION (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0536262-A4 | SUBSTITUTED HISTIDINES | SMITHKLINE BEECHAM CORP (US) | 1996-08-14 | — | — | EP | disclosed |
| US-5444081-A | Treatment of hypertension, congestive heart failure, renal failure, glaucoma | SMITHKLINE BEECHAM CORP (US) | 1995-08-22 | — | — | US | disclosed |
| EP-0536262-A1 | SUBSTITUTED HISTIDINES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1992000068-A1 | SUBSTITUTED HISTIDINES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-09 | — | — | WO | disclosed |