Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Triaziquone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 2/20 | 0.36 |
| ▸ | TDP2 | O95551 | 2/20 | 0.36 |
| ▸ | NSD2 | O96028 | 2/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GALK1 | P51570 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triaziquone SCHEMBL9791390 | 0.98 | DNMT1 (0.42) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL6000230 | 0.90 | DNMT1 (0.47) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL9876358 | 0.90 | DNMT1 (0.47) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL7088197 | 0.90 | DNMT1 (0.47) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL3101456 | 0.90 | DNMT1 (0.47) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL10583104 | 0.88 | DNMT1 (0.47) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL2063810 | 0.88 | MAPT (0.44) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL4608905 | 0.88 | DNMT1 (0.43) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL11120458 | 0.88 | DNMT1 (0.46) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL19995413 | 0.88 | DNMT1 (0.46) | DNMT1MAPTHTTTP53STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 112 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7939645-B2 | Reaction buffer composition for nucleic acid replication with packed DNA polymerases | AGILENT TECHNOLOGIES, INC (US) | 2011-05-10 | — | — | US | claimed |
| EP-1989318-A4 | REACTION BUFFER COMPOSITION FOR NUCLEIC ACID REPLICATION WITH PACKED DNA POLYMERASES | STRATAGENE CALIFORNIA (US) | 2009-08-05 | — | — | EP | claimed |
| EP-1989318-A2 | REACTION BUFFER COMPOSITION FOR NUCLEIC ACID REPLICATION WITH PACKED DNA POLYMERASES | Stratagene California (US) | 2008-11-12 | — | — | EP | claimed |
| US-20080038782-A1 | Reaction buffer composition for nucleic acid replication with packed DNA polymerases | STRATAGENE CALIFORNIA (US) | 2008-02-14 | — | — | US | claimed |
| WO-2007081841-A2 | REACTION BUFFER COMPOSITION FOR NUCLEIC ACID REPLICATION WITH PACKED DNA POLYMERASES | STRATAGENE CALIFORNIA (US) | 2007-07-19 | — | — | WO | claimed |
| WO-2023232096-A1 | AIR SPRAY BASED ON VIRUS BLOCKING AGENT, AND USE THEREOF | 康码（上海）生物科技有限公司 | 2023-12-07 | — | — | WO | disclosed |
| CN-115181616-A | Nucleic acid scavenger based on virus blocking agent and application thereof | 康码（上海）生物科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-114870061-A | Air spray based on virus blocking agent and application thereof | 康码（上海）生物科技有限公司 | 2022-08-09 | — | — | CN | disclosed |
| US-10081806-B2 | Recovery of a biomolecule comprising aqueous phase from a multiphasic mixture | QIAGEN GMBH (DE) | 2018-09-25 | — | — | US | disclosed |
| US-9890374-B2 | Thermostable carbonic anhydrases and methods of use thereof | DANISCO US INC (US) | 2018-02-13 | — | — | US | disclosed |
| EP-2788484-B1 | RECOVERY OF A BIOMOLECULE COMPRISING AQUEOUS PHASE FROM A MULTIPHASIC MIXTURE | QIAGEN GMBH (DE) | 2017-11-01 | — | — | EP | disclosed |
| CN-103547672-B | Thermostable carbonic anhydrases and methods of use thereof | 丹尼斯科美国公司 | 2017-10-27 | — | — | CN | disclosed |
| EP-0290246-A2 | Vaccine for generating an immunogenic T cell response protective against rabies virus | THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 1988-11-09 | — | — | EP | disclosed |
| EP-0146590-A4 | REAGENT FOR COMBINED DILUTING AND LYSING WHOLE BLOOD. | COULTER ELECTRONICS (US) | 1988-09-28 | — | — | EP | disclosed |
| EP-0220966-A2 | Purification method for proteins | CETUS ONCOLOGY CORPORATION (US) | 1987-05-06 | — | — | EP | disclosed |
| US-4529705-A | Quaternary ammonium salt and alkali metal cyanide | COULTER ELECTRONICS, INC. (US) | 1985-07-16 | — | — | US | disclosed |
| EP-0146590-A1 | REAGENT FOR COMBINED DILUTING AND LYSING WHOLE BLOOD | COULTER ELECTRONICS INC. (US) | 1985-07-03 | — | — | EP | disclosed |
| WO-1984004969-A1 | REAGENT FOR COMBINED DILUTING AND LYSING WHOLE BLOOD | COULTER ELECTRONICS (US) | 1984-12-20 | — | — | WO | disclosed |
| US-4302537-A | Reagent and method for the determination of peroxidase | BOEHRINGER MANNHEIM GMBH (DE) | 1981-11-24 | — | — | US | disclosed |
| US-3973002-A | Antihemophilic factor | E. R. SQUIBB & SONS, INC. (US) | 1976-08-03 | — | — | US | disclosed |