SCHEMBL8957322

SCHEMBL8957322

O=[N+]([O-])OCC1CCCCC1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCNA2 P20248 2/20 0.41
CDK2 P24941 2/20 0.41
CCNA1 P78396 2/20 0.41
GSR P00390 2/20 0.39
TLR4 O00206 1/20 0.38
TLR2 O60603 1/20 0.38
CYP19A1 P11511 2/20 0.38
LMNA P02545 1/20 0.37
MMP2 P08253 2/20 0.36
MMP9 P14780 2/20 0.36
ALDH1A1 P00352 1/20 0.36
SLC1A3 P43003 2/20 0.34
SLC1A2 P43004 2/20 0.34
SLC1A1 P43005 2/20 0.34
CTSL P07711 1/20 0.33
CTSB P07858 1/20 0.33
CTSK P43235 1/20 0.33
THRA P10827 1/20 0.33
THRB P10828 1/20 0.33
MEN1 O00255 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8957450 0.93
SCHEMBL23829716 0.88
SCHEMBL6438537 0.88 ALDH1A1 (0.40) CCNA2CDK2CCNA1GSRTLR4
SCHEMBL9875012 0.88 ALDH1A1 (0.40) CCNA2CDK2CCNA1GSRTLR4
SCHEMBL7817737 0.78 MMP2 (0.35) GSRMMP2MMP9ALDH1A1
SCHEMBL8957457 0.78 MMP2 (0.39) CCNA2CDK2CCNA1GSRCYP19A1
SCHEMBL8260874 0.78 TDP1 (0.36) MMP2MMP9ALDH1A1
SCHEMBL9152348 0.78 ALDH1A1 (0.33) MMP2MMP9ALDH1A1
Hydrochloric Acid SCHEMBL7816874 0.77 PLG (0.36) LMNAMMP2MMP9ALDH1A1
Hydrochloric Acid SCHEMBL7816304 0.77 MMP2 (0.34) MMP2MMP9ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0689435-A1 USE OF SUBSTITUTED ALKYL NITRATES FOR THE TREATMENT OF PATHOLOGICALLY INCREASED INTRA-OCULAR PRESSURE BYK NEDERLAND BV (NL) 1996-01-03 EP disclosed
WO-1994021248-A1 USE OF SUBSTITUTED ALKYL NITRATES FOR THE TREATMENT OF PATHOLOGICALLY INCREASED INTRA-OCULAR PRESSURE BYK NEDERLAND BV (NL) 1994-09-29 WO disclosed