Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9874449 | 0.74 | PTGS1 (0.49) | PTGS2LMNAKCNH2HRH1OPRK1 | |
| SCHEMBL4667552 | 0.72 | IDO1 (0.54) | LMNAKCNH2HRH1POLBSMN1; SMN2 | |
| SCHEMBL8957482 | 0.71 | GRIA4 (0.40) | PTGS2LMNACNR1SMN1; SMN2TSHR | |
| SCHEMBL8957402 | 0.69 | GRIN2D (0.49) | PTGS2LMNAPOLBCYP1A2CYP2C19 | |
| SCHEMBL14160199 | 0.68 | LMNA (0.49) | LMNAKCNH2HRH1POLBSMN1; SMN2 | |
| SCHEMBL4669314 | 0.66 | CYP3A4 (0.64) | LMNAKCNH2HRH1OPRK1SMN1; SMN2 | |
| SCHEMBL5190981 | 0.66 | CYP3A4 (0.64) | LMNAKCNH2HRH1OPRK1SMN1; SMN2 | |
| SCHEMBL423397 | 0.66 | LMNA (0.54) | LMNAKCNH2HRH1POLBSMN1; SMN2 | |
| SCHEMBL15929169 | 0.66 | MAPT (0.47) | LMNASMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL197202 | 0.65 | MEN1 (0.62) | LMNAHRH1CNR1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0689435-A1 | USE OF SUBSTITUTED ALKYL NITRATES FOR THE TREATMENT OF PATHOLOGICALLY INCREASED INTRA-OCULAR PRESSURE | BYK NEDERLAND BV (NL) | 1996-01-03 | — | — | EP | claimed |
| WO-1994021248-A1 | USE OF SUBSTITUTED ALKYL NITRATES FOR THE TREATMENT OF PATHOLOGICALLY INCREASED INTRA-OCULAR PRESSURE | BYK NEDERLAND BV (NL) | 1994-09-29 | — | — | WO | claimed |