Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL10558379 | 0.96 | TSHR (0.50) | TSHRHTTMAPTMEN1THRB | |
| Propylene Glycol SCHEMBL22325632 | 0.94 | TSHR (0.48) | TSHRHTTMAPTMEN1THRB | |
| Propylene Glycol SCHEMBL7873540 | 0.94 | TSHR (0.54) | TSHRHTTMAPTMEN1THRB | |
| Propylene Glycol SCHEMBL28125539 | 0.94 | TSHR (0.58) | TSHRHTTMAPTMEN1THRB | |
| Propylene Glycol SCHEMBL55673 | 0.91 | TSHR (0.61) | TSHRHTTMAPTMEN1THRB | |
| Propylene Glycol SCHEMBL4954281 | 0.91 | TSHR (0.61) | TSHRHTTMAPTMEN1THRB | |
| Propylene Glycol SCHEMBL9297699 | 0.90 | TSHR (0.50) | TSHRHTTMAPTMEN1THRB | |
| Propylene Glycol SCHEMBL23159835 | 0.89 | USP2 (0.57) | TSHRHTTMAPTMEN1THRB | |
| Propylene Glycol SCHEMBL3930378 | 0.89 | TSHR (0.58) | TSHRHTTMAPTMEN1THRB | |
| Propylene Glycol SCHEMBL28143445 | 0.89 | TDP1 (0.53) | TSHRHTTMAPTMEN1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5506284-A | BLEND OF CATIONIC POLYMER AND POLYMER MICROPARTICLES CONTAINING TERTIARY AMINO-FUNCTIONAL ACRYLIC POLYMER AND APOLYEPOXIDE | BASF CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |