Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 5/20 | 0.34 |
| ▸ | MMP13 | P45452 | 5/20 | 0.34 |
| ▸ | MMP12 | P39900 | 4/20 | 0.34 |
| ▸ | MMP14 | P50281 | 2/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15974082 | 0.83 | SMN1; SMN2 (0.40) | HSD11B1SMN1; SMN2NPSR1TDP1ALDH1A1 | |
| SCHEMBL15973472 | 0.81 | SMN1; SMN2 (0.41) | HSD11B1SMN1; SMN2NPSR1TDP1GAA | |
| SCHEMBL4546207 | 0.73 | TSHR (0.39) | GAAHPGDMAPK1ALDH1A1ADAMTS5 | |
| SCHEMBL7567717 | 0.69 | BACE1 (0.40) | HSD11B1HPGD | |
| SCHEMBL8958230 | 0.68 | GAA (0.36) | HSD11B1SMN1; SMN2TDP1GAAHPGD | |
| SCHEMBL15974332 | 0.68 | GAA (0.36) | HSD11B1SMN1; SMN2TDP1GAAHPGD | |
| SCHEMBL542612 | 0.68 | LMNA (0.48) | SMN1; SMN2NPSR1ALDH1A1ADAMTS5MMP13 | |
| SCHEMBL13209004 | 0.68 | LMNA (0.48) | SMN1; SMN2NPSR1ALDH1A1ADAMTS5MMP13 | |
| SCHEMBL13209012 | 0.68 | LMNA (0.48) | SMN1; SMN2NPSR1ALDH1A1ADAMTS5MMP13 | |
| SCHEMBL14923368 | 0.67 | HSD11B1 (0.35) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559233-A | 3-/P-PHENYLBENZYL/IMIDAZOLONES AND PYRIMIDONES | SANOFI (FR) | 1996-09-24 | — | — | US | disclosed |
| US-5352788-A | Angiotensin antagonist | ELF SANOFI (FR) | 1994-10-04 | — | — | US | disclosed |
| US-5270317-A | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present | ELF SANOFI (FR) | 1993-12-14 | — | — | US | disclosed |