Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethyl Sulfoxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.36 |
| ▸ | ADH1B | P00325 | 1/20 | 0.35 |
| ▸ | ADH1C | P00326 | 1/20 | 0.35 |
| ▸ | ADH1A | P07327 | 1/20 | 0.35 |
| ▸ | ADH4 | P08319 | 1/20 | 0.35 |
| ▸ | ADH7 | P40394 | 1/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hexane SCHEMBL1303513 | 0.86 | OPRM1 (0.58) | OPRM1LMNACA1SPHK1TP53 | |
| SCHEMBL23993 | 0.86 | — | — | |
| SCHEMBL27784606 | 0.86 | OPRM1 (0.58) | OPRM1LMNACA1SPHK1TP53 | |
| SCHEMBL27976941 | 0.86 | OPRM1 (0.58) | OPRM1LMNACA1SPHK1TP53 | |
| Hexadecane SCHEMBL23000686 | 0.83 | OPRM1 (0.55) | OPRM1LMNASPHK1DNM1ADH1B | |
| SCHEMBL344997 | 0.83 | OPRM1 (0.55) | OPRM1LMNASPHK1DNM1ADH1B | |
| Hydrogen Sulfide SCHEMBL5676370 | 0.83 | — | — | |
| SCHEMBL6122664 | 0.83 | OPRM1 (0.55) | OPRM1LMNASPHK1DNM1ADH1B | |
| SCHEMBL22950680 | 0.83 | OPRM1 (0.55) | OPRM1LMNASPHK1DNM1ADH1B | |
| SCHEMBL671913 | 0.83 | OPRM1 (0.55) | OPRM1LMNASPHK1DNM1ADH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0401503-B1 | Solid non-hygroscopic trialkylamine oxides | ALBEMARLE CORP (US) | 1996-01-17 | — | — | EP | disclosed |
| EP-0401503-A2 | Solid non-hygroscopic trialkylamine oxides | ALBEMARLE CORPORATION (US) | 1990-12-12 | — | — | EP | disclosed |
| US-4960934-A | Amine oxide process | ETHYL CORPORATION (US) | 1990-10-02 | — | — | US | disclosed |