Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 12/20 | 0.51 |
| ▸ | NR1H3 | Q13133 | 12/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | MLYCD | O95822 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8958217 | 0.94 | NR1H2 (0.46) | NR1H2NR1H3EGFRERBB2CNR2 | |
| SCHEMBL8958293 | 0.94 | NR1H2 (0.46) | NR1H2NR1H3EGFRERBB2CNR2 | |
| SCHEMBL9345320 | 0.84 | MEN1 (0.53) | NR1H2NR1H3CNR2KDM4EALDH1A1 | |
| SCHEMBL599438 | 0.80 | NR1H2 (0.58) | NR1H2NR1H3CNR2MLYCDKDM4E | |
| SCHEMBL10473365 | 0.78 | NR1H2 (0.44) | NR1H2NR1H3EGFRERBB2CNR2 | |
| SCHEMBL7153351 | 0.78 | EGFR (0.50) | NR1H2NR1H3EGFRERBB2CNR2 | |
| SCHEMBL10473275 | 0.78 | NR1H2 (0.46) | NR1H2NR1H3EGFRERBB2CNR2 | |
| SCHEMBL472266 | 0.77 | EGFR (0.58) | EGFRERBB2CNR2KDM4EALDH1A1 | |
| SCHEMBL5283357 | 0.77 | NR1H2 (0.47) | NR1H2NR1H3EGFRERBB2NR1I2 | |
| SCHEMBL11373304 | 0.76 | EGFR (0.56) | EGFRERBB2CNR2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0535842-B1 | Benzofuranones | ZENECA LTD (GB) | 1996-01-10 | — | — | EP | disclosed |
| US-5389597-A | For dye diffusion thermal transfer printing | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-02-14 | — | — | US | disclosed |
| US-5268490-A | With indan-1,3-dione and aminobenzene ring | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-12-07 | — | — | US | disclosed |
| EP-0535842-A1 | Benzofuranones | ZENECA LIMITED (GB) | 1993-04-07 | — | — | EP | disclosed |