Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.46 |
| ▸ | CNR2 | P34972 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | MLYCD | O95822 | 3/20 | 0.41 |
| ▸ | ICMT | O60725 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8958293 | 1.00 | NR1H2 (0.46) | NR1H2NR1H3CNR2NPC1JAK2 | |
| SCHEMBL8958343 | 0.94 | NR1H2 (0.51) | NR1H2NR1H3CNR2EGFRERBB2 | |
| SCHEMBL9345320 | 0.82 | MEN1 (0.53) | NR1H2NR1H3CNR2NPC1RAB9A | |
| SCHEMBL1815516 | 0.79 | CNR2 (0.46) | CNR2NPC1JAK2RAB9APAX8 | |
| SCHEMBL12677177 | 0.79 | CNR2 (0.46) | CNR2NPC1JAK2RAB9APAX8 | |
| SCHEMBL10471667 | 0.79 | CNR2 (0.48) | NR1H2NR1H3CNR2NPC1JAK2 | |
| SCHEMBL11539577 | 0.79 | PTGES (0.54) | CNR2EGFRERBB2 | |
| SCHEMBL472312 | 0.79 | PTGES (0.54) | CNR2EGFRERBB2 | |
| SCHEMBL1134696 | 0.79 | PTGES (0.54) | CNR2EGFRERBB2 | |
| SCHEMBL3786342 | 0.79 | PTGES (0.54) | CNR2EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0535842-B1 | Benzofuranones | ZENECA LTD (GB) | 1996-01-10 | — | — | EP | disclosed |
| US-5389597-A | For dye diffusion thermal transfer printing | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-02-14 | — | — | US | disclosed |
| US-5268490-A | With indan-1,3-dione and aminobenzene ring | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-12-07 | — | — | US | disclosed |
| EP-0535842-A1 | Benzofuranones | ZENECA LIMITED (GB) | 1993-04-07 | — | — | EP | disclosed |