Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 3/20 | 0.75 |
| ▸ | HRH1 | P35367 | 12/20 | 0.74 |
| ▸ | SLC6A15 | Q9H2J7 | 5/20 | 0.74 |
| ▸ | FNTA | P49354 | 3/20 | 0.74 |
| ▸ | FNTB | P49356 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.70 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.70 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.70 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.70 |
| ▸ | HTR1A | P08908 | 1/20 | 0.70 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.70 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.70 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.70 |
| ▸ | DRD2 | P14416 | 1/20 | 0.70 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.70 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.70 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.70 |
| ▸ | DRD1 | P21728 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4460572 | 0.89 | HRH1 (0.82) | PTAFRHRH1SLC6A15FNTAFNTB | |
| SCHEMBL31384618 | 0.89 | HRH1 (0.82) | PTAFRHRH1SLC6A15FNTAFNTB | |
| SCHEMBL29626502 | 0.89 | HRH1 (0.82) | PTAFRHRH1SLC6A15FNTAFNTB | |
| SCHEMBL20777155 | 0.88 | PTAFR (0.75) | PTAFRHRH1SLC6A15FNTAFNTB | |
| SCHEMBL3367280 | 0.86 | SLC6A15 (0.82) | PTAFRHRH1SLC6A15FNTAFNTB | |
| SCHEMBL31305643 | 0.86 | PTAFR (1.00) | PTAFRHRH1SLC6A15FNTAFNTB | |
| SCHEMBL8876967 | 0.86 | PTAFR (1.00) | PTAFRHRH1SLC6A15FNTAFNTB | |
| SCHEMBL8878295 | 0.85 | SLC6A15 (0.80) | PTAFRHRH1SLC6A15FNTAFNTB | |
| Sch-37370 SCHEMBL3071641 | 0.85 | PTAFR (1.00) | PTAFRHRH1SLC6A15FNTAFNTB | |
| SCHEMBL2738854 | 0.85 | PTAFR (0.71) | PTAFRHRH1SLC6A15FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8187630-B2 | Extended release oral dosage composition | SCHERING-PLOUGH CORPORATION (US) | 2012-05-29 | — | — | US | disclosed |
| US-8187630-B2 | Extended release oral dosage composition | SCHERING-PLOUGH CORPORATION (US) | 2012-05-29 | — | — | US | disclosed |
| US-20100021542-A1 | EXTENDED RELEASE ORAL DOSAGE COMPOSITION | SCHERING CORPORATION (US) | 2010-01-28 | — | — | US | disclosed |
| US-20100021542-A1 | EXTENDED RELEASE ORAL DOSAGE COMPOSITION | SCHERING CORPORATION (US) | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100021542-A1 | EXTENDED RELEASE ORAL DOSAGE COMPOSITION | HRH2, QDPR, HRH1 | PTAFR 1672/4885HRH1 3/4885SLC6A15 2682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.