Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGMT | P16455 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31439118 | 0.84 | MPO (0.44) | MGMTCYP3A4CDK1CCNB1CCNA2 | |
| SCHEMBL14998811 | 0.83 | DYRK1A (0.48) | MGMTCYP3A4CDK1CCNB1CCNA2 | |
| SCHEMBL29661259 | 0.83 | PIN1 (0.46) | MGMTCYP3A4CDK1CCNB1CCNA2 | |
| 6-O-Benzylguanine SCHEMBL29405347 | 0.83 | MGMT (0.63) | MGMTCYP3A4CDK1CCNB1CCNA2 | |
| 6-O-Benzylguanine SCHEMBL600698 | 0.83 | MGMT (0.63) | MGMTCYP3A4CDK1CCNB1CCNA2 | |
| SCHEMBL7437643 | 0.83 | PIN1 (0.46) | MGMTCYP3A4CDK1CCNB1CCNA2 | |
| 6-O-Benzylguanine SCHEMBL4631743 | 0.82 | MGMT (0.61) | MGMTCYP3A4CDK1CCNB1CCNA2 | |
| SCHEMBL821766 | 0.78 | CDC7 (0.60) | MGMTCYP3A4CDK1CCNB1CCNA2 | |
| SCHEMBL21591842 | 0.78 | MPO (0.43) | MGMTCYP3A4CDK1CCNB1CCNA2 | |
| 6-O-Benzylguanine SCHEMBL4869637 | 0.78 | MGMT (0.56) | MGMTCYP3A4CDK1CCNB1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0523100-B1 | O6 -BENZYLATED GUANINE, GUANOSINE AND 2'-DEOXYGUANOSINE COMPOUNDS POSSESSING O6 -ALKYLGUANINE-DNA ALKYLTRANSFERASE DEPLETING ACTIVITY | US HEALTH (US) | 1996-08-28 | — | — | EP | disclosed |
| EP-0691981-A1 | TUMOR TARGETING WITH L-ENANTIOMERIC OLIGONUCLEOTIDE CONJUGATES OF IMMUNOREAGENTS AND OF CHELATED RADIONUCLIDES | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994020523-A1 | TUMOR TARGETING WITH L-ENANTIOMERIC OLIGONUCLEOTIDE CONJUGATES OF IMMUNOREAGENTS AND OF CHELATED RADIONUCLIDES | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-09-15 | — | — | WO | disclosed |